Este abril de 2022 hizo su aparición estelar un artículo científico¹, ni más ni menos que en la supraprestigiosa revista Nature, uno de los medios más influyentes (por no decir abiertamente el más respetado) de la ciencia académica universal. Aquel obcecado «comer grasa provoca cáncer colorrectal» (que los ketofílicos llevábamos décadas sorteando) pasó a la historia por fin.
No exagero, no. El título del estudio no puede ser más esclarecedor, porque reza textualmente «el β-hidroxibutirato suprime el cáncer colorrectal».
Contenido adicional restringido. Para acceder a él, elige tu recorrido y adquiere tu dorsal.
¡Aúpa keto!
(1). Dmitrieva-Posocco, O., Wong, A. C., Lundgren, P., Golos, A. M., Descamps, H. C., Dohnalová, L., Cramer, Z., Tian, Y., Yueh, B., Eskiocak, O., Egervari, G., Lan, Y., Liu, J., Fan, J., Kim, J., Madhu, B., Schneider, K. M., Khoziainova, S., Andreeva, N., … Levy, M. (2022). β-Hydroxybutyrate suppresses colorectal cancer. Nature, 605(7908), 160-165. https://doi.org/10.1038/s41586-022-04649-6
¿Quieres oír los episodios antes que nadie?
¿Quieres oír los episodios antes que nadie? Suscríbete al podcast en ivoox o escúchalos en Amazon Music, Apple Podcasts, Spotify Podcasts y SoundCloud.
¿Quieres, además, oírlo sin anuncios y descargarte la transcripción referenciada? ¡Consigue tu dorsal o tu pase VIP para la maratón y regodéate en las ketofilias VIP’s!
Bibliografía recomendada
Apple, S. (2021). Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection. Disponible en Amazon.
Baker, S. (2019). Carnivore Diet. Disponible en Amazon.
Christofferson, T. (2018). Cáncer. La sorprendente verdad. La teoría metabólica, la dieta cetogénica y una nueva y esperanzadora vía para la curación del cáncer. Disponible en Amazon.
Connealy, L. E. (2017). The Cancer Revolution: A groundbreaking program to reverse and prevent cancer. Disponible en Amazon.
Kalamian, M., & Seyfried, T. N. (2019). Ceto para el cáncer. El empleo de la terapia metabólica cetogénica como estrategia nutricional. Disponible en Amazon.
Mukherjee, S. (2011). The Emperor of All Maladies: A Biography of Cancer. Disponible en Amazon.
Rockermeier, J., Seyfried, T., & D’Agostino, D. (2020). Summary of: Cancer as a Metabolic Disease by Dr. Thomas Seyfried. On the Origin, Management, and Prevention of Cancer. Disponible en Amazon.
Rodgers, D., & Wolf, R. (2020). Sacred Cow: The Case for (Better) Meat: Why Well-Raised Meat Is Good for You and Good for the Planet. Disponible en Amazon.
Saladino, P. (2020). The Carnivore Code: Unlocking the Secrets to Optimal Health by Returning to Our Ancestral Diet. Disponible en Amazon.
Winters, N., & Higgins Kelley, J. (2016). La estrategia Metabólica contra el Cáncer: Plan intensivo de nutrición, dieta cetogénica y terapias no tóxicas biopersonalizadas. Disponible en Amazon.
(Y para auténticos forofos de la causa): Seyfried, T. (2012). Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. Disponible en Amazon.
Referencias
Astrup, A., Magkos, F., Bier, D. M., Brenna, J. T., de Oliveira Otto, M. C., Hill, J. O., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 76(7), 844-857. https://doi.org/10.1016/j.jacc.2020.05.077
Bansal, V., & Kim, K.-H. (2015). Review of PAH contamination in food products and their health hazards. Environment International, 84, 26-38. https://doi.org/10.1016/j.envint.2015.06.016
Beyaz, S., Mana, M. D., Roper, J., Kedrin, D., Saadatpour, A … Yilmaz, Ö. H. (2016). High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature, 531(7592), 53-58. https://doi.org/10.1038/nature17173
Bouvard, V., Loomis, D., Guyton, K. Z., Grosse, Y., Ghissassi, F. E., … Straif, K., & International Agency for Research on Cancer Monograph Working Group. (2015). Carcinogenicity of consumption of red and processed meat. The Lancet. Oncology, 16(16), 1599-1600. https://doi.org/10.1016/S1470-2045(15)00444-1
Chan, D. S. M., Lau, R., Aune, D., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2011). Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies. PLOS ONE, 6(6), e20456. https://doi.org/10.1371/journal.pone.0020456
Chen, X., Liang, H., Song, Q., Xu, X., & Cao, D. (2018). Insulin promotes progression of colon cancer by upregulation of ACAT1. Lipids in Health and Disease, 17(1), 122. https://doi.org/10.1186/s12944-018-0773-x
Dmitrieva-Posocco, O., Wong, A. C., Lundgren, P., Golos, A. M., Descamps, H. C., Dohnalová, L., Cramer, Z., Tian, Y., Yueh, B., Eskiocak, O., Egervari, G., Lan, Y., Liu, J., Fan, J., Kim, J., Madhu, B., Schneider, K. M., Khoziainova, S., Andreeva, N., … Levy, M. (2022). β-Hydroxybutyrate suppresses colorectal cancer. Nature, 605(7908), 160-165. https://doi.org/10.1038/s41586-022-04649-6
Fogelholm, M., Kanerva, N., & Männistö, S. (2015). Association between red and processed meat consumption and chronic diseases: The confounding role of other dietary factors. European Journal of Clinical Nutrition, 69(9), 1060-1065. https://doi.org/10.1038/ejcn.2015.63
Goncalves, M. D., Lu, C., Tutnauer, J., Hartman, T. E., Hwang, S.-K., … Yun, J. (2019). High-fructose corn syrup enhances intestinal tumor growth in mice. Science, 363(6433), 1345-1349. https://doi.org/10.1126/science.aat8515
Hackett, A. (2011). Food Frequency Questionnaires: Simple and cheap, but are they valid? Maternal & Child Nutrition, 7(2), 109-111. https://doi.org/10.1111/j.1740-8709.2011.00314.x
Hindson, J. (2022). CRC inhibited by the ketone body β-hydroxybutyrate. Nature Reviews Gastroenterology & Hepatology, 19(7), 416-416. https://doi.org/10.1038/s41575-022-00636-4
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2018). Red Meat and Processed Meat. International Agency for Research on Cancer. http://www.ncbi.nlm.nih.gov/books/NBK507971/
Klurfeld, D. M. (2015). Research gaps in evaluating the relationship of meat and health. Meat Science, 109, 86-95. https://doi.org/10.1016/j.meatsci.2015.05.022
Miller, P. E., Alexander, D. D., & Weed, D. L. (2014). Uncertainty of Results in Nutritional Epidemiology. Nutrition Today. https://doi.org/10.1097/NT.0000000000000027
Oostindjer M, Alexander J, Amdam GV, Andersen G, Bryan NS, Chen D, et al. The role of red and processed meat in colorectal cancer development: a perspective. Meat Science. 2014;97(4):583-96. https://pubmed.ncbi.nlm.nih.gov/24769880/
Pakneshan, S., Salajegheh, A., Smith, R. A., & Lam, A. K.-Y. (2013). Clinicopathological relevance of BRAF mutations in human cancer. Pathology, 45(4), 346-356. https://doi.org/10.1097/PAT.0b013e328360b61d
Sasaki, K., Sasaki, D., Hannya, A., Tsubota, J., & Kondo, A. (2020). In vitro human colonic microbiota utilises D-β-hydroxybutyrate to increase butyrogenesis. Scientific Reports, 10(1), 8516. https://doi.org/10.1038/s41598-020-65561-5
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., Newgard, C. B., Farese, R. V., de Cabo, R., Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor. Science, 339(6116), 211-214. https://doi.org/10.1126/science.1227166
Steinberg, P. (2019). Red Meat-Derived Nitroso Compounds, Lipid Peroxidation Products and Colorectal Cancer. Foods, 8(7), 252. https://doi.org/10.3390/foods8070252
Tan-Shalaby, J. (2017). Ketogenic Diets and Cancer: Emerging Evidence. Federal Practitioner, 34(Suppl 1), 37S-42S.
Xia, S., Lin, R., Jin, L., Zhao, L., Kang, H.-B., Pan, Y., Liu, S., Qian, G., Qian, Z., Konstantakou, E., Zhang, B., Dong, J.-T., Chung, Y. R., Abdel-Wahab, O., Merghoub, T., Zhou, L., Kudchadkar, R. R., Lawson, D. H., Khoury, H. J., … Chen, J. (2017). Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism, 25(2), 358-373. https://doi.org/10.1016/j.cmet.2016.12.010
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D’Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., Kang, S., Horvath, T. L., Fahmy, T. M., Crawford, P. A., Biragyn, A., Alnemri, E., & Dixit, V. D. (2015). The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine, 21(3), 263-269. https://doi.org/10.1038/nm.3804
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022). Ketogenic diet for human diseases: The underlying mechanisms and potential for clinical implementations. Nature: Signal Transduction and Targeted Therapy, 7(1), 11. https://doi.org/10.1038/s41392-021-00831-w
Zur Hausen, H. (2012). Red meat consumption and cancer: Reasons to suspect involvement of bovine infectious factors in colorectal cancer. International Journal of Cancer, 130(11), 2475-2483. https://doi.org/10.1002/ijc.27413
